A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G
نویسندگان
چکیده
منابع مشابه
A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G
APOBEC3G is the best known of several DNA cytosine deaminases that function to inhibit the replication of parasitic genetic elements including the lentivirus HIV. Several high-resolution structures of the APOBEC3G catalytic domain have been generated, but none reveal how this enzyme binds to substrate single-stranded DNA. Here, we constructed a panel of APOBEC3G amino acid substitution mutants ...
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ژورنال
عنوان ژورنال: Biology
سال: 2012
ISSN: 2079-7737
DOI: 10.3390/biology1020260